|
|
 |
 |
 |
Bruce
Klitzman, Ph.D.
(Physiology, University of Virginia)
Associate
Research Professor, Departments of Surgery, Cell Biology,
and Biomedical Engineering
Senior Director, Kenan Plastic Surgery Research Laboratories
|
Research
interests are in the area of tissue engineering and physiological
mechanisms of controlling transport from blood to tissue.
This broad topic covers basic and clinical studies on
a whole animal, whole organ, microvascular, cellular,
ultrastructural, and molecular level. The current projects
include:
1) control of total blood flow and flow distribution in
the microcirculation in normal and in pathological states
such as wounds, tumors, and traumatized tissue;
2) angiogenesis stimulation and inhibition;
3) improving the biocompatibility and performance of synthetic
and biosynthetic blood vessels;
4) controlling the development of tumor microcirculation
and its effect on oxygenation;
5) measurement of tissue blood flow and oxygenation as
a predictor of tissue damage or ability to heal; and
6) sampling of extracellular fluid using microdialysis
to measure metabolites and drug delivery. |
|
|
E-mail
klitz@duke.edu
019
Research Park IV, Box 3906
Duke University Medical Center
Durham, NC 27710
Telephone
919-684-6686, 919-684-3929
Fax 509-277-6943
|
Selected
Publications
Dewhirst, M.W., Ong E.T., Braun, R.D., Smith B., Klitzman
B., Evans S.M., and Wilson D. Quantification of longitudinal
tissue PO2 gradients in window chamber tumors: impact
on tumor hypoxia. Br. J. Cancer 79:1717-1722, 1999.
Klitzman B., R.D. Braun, A.C. Lockhart, L. Heller, M.W.
Dewhirst, and H.I. Hurwitz. Wound-induced angiogenesis:
A clinical model. Prog Appl Microcirc 24:11-15, 2000.
Dewhirst, MW, Klitzman B., Braun, R.D., Brizel, D.M.,
Haroon, Z.A., and Secomb, T.W. Review of methods to study
oxygen transport at the microcirculatory level. Int. J.
Cancer (Radiat. Oncol. Invest.) 90:237-255, 2000.
Moore, F.M., Klitzman, B., Levin, L.S., and Brown, S.A.
Tumor necrosis factor-alpha levels in crushed rat muscle.
Plast Reconstr Surg in press, 2001.
Ravin, AG, Olbrich, K.C., Levin, L.S., Usala, A.L., Klitzman,
B. Long- and short-term effects of biological hydrogels
on capsule microvascular density around implants in rats.
J. Biomed. Mater. Res. (Appl. Biomat.), in press, 2001.
Sundin BM.., Hussein, M.A., Glasofer, S, El-Falaky, M.H.,
Abdel-Aleem, S.M., Sachse, R.E., and Klitzman, B. The
role of allopurinol and deferoxamine in prevention of
pressure ulcers in pigs. Plast Reconstr Surg 104:1408-1421,
2000. |
Current
Projects
Kevn Olbrich (junior faculty): Enhanced mass transport
into and out of medical devices; Inhibition of the foreign
body reaction to chronically implanted medical devices.
Natalie Wisniewski (Ph.D. student in Biomedical Engineering):
Biocompatibility of biosensors: Use of microdialysis to
quantify the tissue effects on mass transport to implanted
devices.
Ranya Sweis (medical student): Angiogenesis associated
with chronically implanted devices.
Christiane Poellmann (medical student): Tumor metabolites:
Effects of hyperglycemia on tumor pH.
Mark Dewhirst (collaborator): Oxygenation of tumors. |
<<Back
to the top
|
|
|
