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Protein synthesis regulation:
What role does
protein synthesis play in the regulation of ribosome
binding and release on the ER?
How is the protein synthesis
activity of ER-bound ribosomes regulated during normal
and stress conditions?
What is the mechanism of mRNA
targeting to, and release from, the ER membrane?
(subclasses of) mRNAs contain ER-directed localization
How are GRP94 interactions with
polypeptide substrates regulated?
What is the identity
of the GRP94 "proteome"?
(those proteins whose functional expression requires
How is GRP94 recognized
by the cells of the immune system?